Timothy D Le Cras Selected Research

Transforming Growth Factor alpha (TGF-alpha)

1/2017	Optical coherence tomography-based contact indentation for diaphragm mechanics in a mouse model of transforming growth factor alpha induced lung disease.
2/2010	Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.
11/2009	Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
10/2009	Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.
6/2008	EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.
9/2007	Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.
8/2007	Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.
4/2004	Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.
11/2003	Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha.

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Timothy D Le Cras Research Topics

Disease

10	Inflammation (Inflammations) 02/2016 - 04/2004
8	Asthma (Bronchial Asthma) 02/2016 - 10/2009
7	Pulmonary Hypertension 01/2019 - 09/2002
6	Pulmonary Fibrosis (Fibrosing Alveolitis) 02/2010 - 04/2004
5	Fibrosis (Cirrhosis) 01/2017 - 04/2004
5	Vascular Remodeling 06/2008 - 05/2003
4	Lung Diseases (Lung Disease) 01/2017 - 11/2003
4	Respiratory Hypersensitivity 02/2016 - 10/2009
3	Weight Loss (Weight Reduction) 02/2010 - 06/2008
2	Hypoxia (Hypoxemia) 01/2019 - 08/2004
2	Body Weight (Weight, Body) 12/2011 - 04/2004
2	Metaplasia 12/2011 - 03/2011
2	Hyperplasia 01/2011 - 05/2003
2	Lung Injury 10/2009 - 06/2008
1	Acute Kidney Injury (Acute Renal Failure) 01/2021
1	COVID-19 01/2021
1	Emphysema 01/2020
1	Hypersensitivity (Allergy) 01/2018
1	Eosinophilia 02/2016
1	Familial Primary Pulmonary Hypertension 01/2012
1	Airway Remodeling 12/2011
1	Idiopathic Pulmonary Fibrosis 09/2007
1	Cachexia 09/2007
1	Bronchopulmonary Dysplasia 08/2007
1	Respiratory Insufficiency (Respiratory Failure) 01/2005
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2005
1	Hypertrophy 12/2004
1	Chorioamnionitis 12/2004
1	Vascular Diseases (Vascular Disease) 11/2003

Drug/Important Bio-Agent (IBA)

9	Transforming Growth Factor alpha (TGF-alpha)IBA 01/2017 - 11/2003
6	CollagenIBA 12/2011 - 04/2004
5	CytokinesIBA 02/2016 - 04/2004
5	ErbB Receptors (EGF Receptor)IBA 12/2011 - 11/2003
4	AllergensIBA 02/2016 - 01/2011
4	Sirolimus (Rapamycin)FDA Link 01/2013 - 11/2009
3	Doxycycline (Periostat)FDA LinkGeneric 01/2018 - 06/2008
3	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2018 - 11/2003
3	Interleukin-13IBA 02/2016 - 12/2011
3	Methacholine Chloride (Methacholine)FDA Link 01/2012 - 10/2009
3	Transcription Factors (Transcription Factor)IBA 01/2011 - 08/2004
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2020 - 09/2002
2	LeukotrienesIBA 02/2016 - 12/2011
2	1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA 11/2013 - 01/2013
2	Vehicle Emissions (Emissions, Vehicle)IBA 11/2013 - 01/2013
2	Immunoglobulin E (IgE)IBA 01/2013 - 12/2011
2	Cysteine (L-Cysteine)FDA Link 01/2013 - 09/2007
2	Messenger RNA (mRNA)IBA 12/2011 - 08/2004
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 03/2011 - 06/2008
2	Proteins (Proteins, Gene)FDA Link 09/2007 - 12/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2005 - 11/2003
1	Angiopoietin-2IBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2019
1	OvalbuminIBA 01/2018
1	Placenta Growth FactorIBA 02/2016
1	EnzymesIBA 02/2016
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 02/2016
1	Interleukin-17 (Interleukin 17)IBA 11/2013
1	ChemokinesIBA 01/2013
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2013
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2012
1	Therapeutic UsesIBA 12/2011
1	Fibronectins (Fibronectin)IBA 12/2011
1	PX-866IBA 02/2010
1	TOR Serine-Threonine KinasesIBA 11/2009
1	Gefitinib (Iressa)FDA Link 06/2008
1	Tyrosine Kinase InhibitorsIBA 06/2008
1	Extracellular Matrix ProteinsIBA 09/2007
1	Endothelin Receptors (Endothelin Receptor)IBA 09/2007
1	Serine (L-Serine)FDA Link 09/2007
1	OsteopontinIBA 09/2007
1	TenascinIBA 09/2007
1	CaveolinsIBA 09/2007
1	Protease Inhibitors (Protease Inhibitor)IBA 09/2007
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 09/2007
1	Growth Factor ReceptorsIBA 08/2007
1	EndotoxinsIBA 12/2004
1	myocardinIBA 08/2004
1	MidkineIBA 08/2004
1	Transforming Growth Factor beta (TGF-beta)IBA 04/2004
1	Interleukin-6 (Interleukin 6)IBA 04/2004
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2004
1	MitogensIBA 05/2003
1	Platelet-Derived Growth FactorIBA 05/2003
1	Semaxinib (SU5416)IBA 09/2002

Therapy/Procedure

2	Therapeutics 12/2011 - 02/2010